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KMID : 0369820160460010055
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Jorunal of Korean Pharmaceutical Sciences
2016 Volume.46 No. 1 p.55 ~ p.66
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Formulation consideration and skin retention study of microemulsion containing tazarotene for targeted therapy of acne
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Patel Mrunali R.
Patel Rashmin B.
Parikh Jolly R.
Patel Bharat G.
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Abstract
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The objective of this study was to develop and evaluate a novel microemulsion (ME) formulation containing tazarotene for targeted topical therapy of acne. Microemulsions (MEs) were formulated by spontaneous microemulsification method using 12 % Isopropyl myristate, mixed emulsifiers 15 % Labrasol-Cremophor-RH 40 (1:1), 15 % Capmul MCM and 58 % water (w/w) as an external phase. All plain and tazarotene loaded MEs were clear and showed physicochemical parameters for desired topical delivery and stability. The permeation profile of tazarotene through rat skin from selected ME formulation exhibited highest skin uptake. The microscopic observations indicated that the optimized ME had no significant effect on the microscopic structure of the skin and epithelial cells appeared mostly unchanged. The surface epithelium lining and the granular cellular structure of the skin were totally intact. The developed ME may be a potential drug delivery vehicle for targeted topical delivery of tazarotene in the treatment of acne.
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KEYWORD
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Acne, Microemulsion, Skin retention study, Tazarotene, Topical drug delivery
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